Linifanib – a multi-targeted receptor tyrosine kinase inhibitor and a low molecular weight gelator

Marlow, Maria and Al-Ameedee, Mohammed and Smith, Thomas and Wheeler, Simon and Stocks, Michael J. (2015) Linifanib – a multi-targeted receptor tyrosine kinase inhibitor and a low molecular weight gelator. Chemical Communications, 51 . pp. 6384-6387. ISSN 1364-548X

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Abstract

In this study we demonstrate that linifanib, a multi-targeted receptor tyrosine kinase inhibitor, with a key urea containing pharmacophore, self-assembles into a hydrogel in the presence of low amounts of solvent. We demonstrate the role of the urea functional group and that of fluorine substitution on the adjacent aromatic ring in promoting self-assembly. We have also shown that linifanib has superior mechanical strength to two structurally related analogues and hence increased potential for localisation at an injection site for drug delivery applications.

Item Type: Article
Schools/Departments: University of Nottingham, UK > Faculty of Science > School of Pharmacy
Identification Number: 10.1039/c5cc00454c
Depositing User: Eprints, Support
Date Deposited: 21 Nov 2017 09:37
Last Modified: 24 Nov 2017 12:08
URI: http://eprints.nottingham.ac.uk/id/eprint/48294

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