Iron-catalyzed indolizine synthesis from pyridines, diazo compounds, and alkynes

Douglas, Tim and Pordea, Anca and Dowden, James (2017) Iron-catalyzed indolizine synthesis from pyridines, diazo compounds, and alkynes. Organic Letters, 19 (23). pp. 6396-6399. ISSN 1523-7052

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Abstract

The iron (III) catalyzed synthesis of indolizines from commercially available alkyne, pyridine, and diazo precursors is reported. This mild, expedient method is tolerant of various solvents and proceeds with as little as 0.25 mol % [Fe(TPP)Cl]. Significantly, this multicomponent reaction is compatible with electrophilic alkynes; control experiments demonstrate the importance of the catalyst in promoting pyridinium ylide formation over background reactivity.

Item Type: Article
RIS ID: https://nottingham-repository.worktribe.com/output/895207
Schools/Departments: University of Nottingham, UK > Faculty of Engineering > Department of Chemical and Environmental Engineering
University of Nottingham, UK > Faculty of Science > School of Chemistry
Identification Number: https://doi.org/10.1021/acs.orglett.7b03252
Depositing User: Eprints, Support
Date Deposited: 20 Nov 2017 13:52
Last Modified: 04 May 2020 19:17
URI: http://eprints.nottingham.ac.uk/id/eprint/48261

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