Antimicrobial & antimicrobial resistance

Scales, Danielle (2017) Antimicrobial & antimicrobial resistance. MRes thesis, University of Nottingham.

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Abstract

By 2050, it is expected that antimicrobial resistance (AMR) will overtake cancer to become the world’s biggest killer. As the pharmaceutical industry spends less on antibiotic research and development, universities have an increasing role to play. As part of this degree, my two research projects approach AMR from different angles. The first takes a traditional approach to AMR, and uses transposon mutagenesis to identify novel novobiocin resistance mechanisms in Klebsiella pneumoniae. The second takes a genotypic approach and explores the application of anti-virulence drugs, which inhibit IscR in Yersinia pseudotuberculosis to disarm rather than kill the bacteria. Diversification is essential for the development of novel antimicrobial strategies.

Item Type: Thesis (University of Nottingham only) (MRes)
Supervisors: Williams, P .
Subjects: Q Science > QR Microbiology > QR171 Microorganisms in the animal body
Faculties/Schools: UK Campuses > Faculty of Science > School of Biosciences
Item ID: 48146
Depositing User: Scales, Danielle
Date Deposited: 12 Jan 2018 14:07
Last Modified: 13 Jan 2018 12:13
URI: http://eprints.nottingham.ac.uk/id/eprint/48146

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