Sodium MRI: a new frontier in imaging in nephrology

Francis, Susan T. and Buchanan, Charlotte and Prestwich, Benjamin and Taal, Maarten W. (2017) Sodium MRI: a new frontier in imaging in nephrology. Current Opinion in Nephrology and Hypertension, 26 (6). pp. 435-441. ISSN 1473-6543

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Abstract

Purpose of review

This review focuses on the recent technological advances in quantitative sodium (23Na) MRI to provide a noninvasive measure of tissue viability for use in clinical studies of patients with kidney disease. 23Na MRI is the only non-invasive imaging technique that allows for the absolute spatial quantification of tissue sodium concentration (TSC), providing assessment of the corticomedullary sodium gradient (CMSG) in the kidney, and allowing measures of TSC in the skin and muscle.

Recent findings

23Na MRI of the kidney has demonstrated the sensitivity to measure the CMSG, providing the normal range in healthy subjects and demonstrating a reduction in CMSG in kidney disease and transplanted kidneys. Studies using 23Na and 1H MRI have shown that in humans skeletal muscle and skin can store sodium without water retention, and that sodium concentrations in muscle and skin increase with advancing age. Recent studies have shown that TSC can be mobilised during haemodialysis, and that skin sodium content links closely to left ventricular mass in patients with Chronic Kidney Disease.

Summary

23Na MRI is currently a research technique, but with future advances, 23Na MRI has potential to become a noninvasive renal biomarker to measure tissue sodium storage for clinical studies.

Item Type: Article
Additional Information: This is a non-final version of an article published in final form in Sodium MRI: a new frontier in imaging in nephrology Francis, Susana; Buchanan, Charlotte E.A.; Prestwich, Bena; Taal, Maarten W. Current Opinion in Nephrology & Hypertension: November 2017 Volume 26 - Issue 6 - p 435–441 doi: 10.1097/MNH.0000000000000370
Keywords: Sodium MRI; Kidney; Skin; Muscle; Clinical
Schools/Departments: University of Nottingham, UK > Faculty of Medicine and Health Sciences > School of Medicine > Division of Medical Sciences and Graduate Entry Medicine
University of Nottingham, UK > Faculty of Science > School of Physics and Astronomy
Identification Number: 10.1097/MNH.0000000000000370
Depositing User: Francis, Susan
Date Deposited: 23 Oct 2017 14:24
Last Modified: 23 Oct 2017 23:13
URI: http://eprints.nottingham.ac.uk/id/eprint/47421

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