Core outcome sets in dermatology: report from the second meeting of the International Cochrane Skin Group Core Outcome Set Initiative

Kottner, Jan and Jacobi, Lena and Hahnel, Elisabeth and Alam, Murad and Beeckman, Dimitri and Busard, Celine and Chalmers, J.R. and Deckert, Stefanie and Eleftheriadou, Viktoria and Furlan, Karina and Horbach, Sophie E.R. and Kirkham, Jamie J. and Nast, Alexander and Thiboutot, Diane and Thorlacius, Linnea and Weller, Karsten and Williams, Hywel C. and Schmitt, Jochen (2018) Core outcome sets in dermatology: report from the second meeting of the International Cochrane Skin Group Core Outcome Set Initiative. British Journal of Dermatology, 178 (4). e279-e285. ISSN 1365-2133

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Abstract

Results of clinical trials are the most important information source for generating external clinical evidence. The use of different outcomes across trials, which investigate similar interventions for similar patient groups, significantly limits the interpretation, comparability and clinical application of trial results. Core outcome sets (COSs) aim to overcome this limitation. A COS is an agreed standardized collection of outcomes that should be measured and reported in all clinical trials for a specific clinical condition. The Core Outcome Set Initiative within the Cochrane Skin Group (CSG-COUSIN) supports the development of core outcomes in dermatology.

In the second CSG-COUSIN meeting held in 2017, 11 COS development groups working on skin diseases presented their current work. The presentations and discussions identified the following overarching methodological challenges for COS development in dermatology: it is not always easy to define the disease focus of a COS; the optimal method for outcome domain identification and level of detail needed to specify such domains is challenging to many; decision rules within Delphi surveys need to be improved; appropriate ways of patient involvement are not always clear. In addition, there appear to be outcome domains that may be relevant as potential core outcome domains for the majority of skin diseases. The close collaboration between methodologists in the Core Outcome Set Initiative and the international Cochrane Skin Group has major advantages for trialists, systematic reviewers and COS developers.

Item Type: Article
Schools/Departments: University of Nottingham, UK > Faculty of Medicine and Health Sciences > School of Medicine > Division of Rheumatology, Orthopaedics and Dermatology
Identification Number: https://doi.org/10.1111/bjd.16324
Depositing User: Eprints, Support
Date Deposited: 20 Oct 2017 11:12
Last Modified: 01 May 2018 14:43
URI: http://eprints.nottingham.ac.uk/id/eprint/47409

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