Gene therapy using plasmid DNA encoding vascular endothelial growth factor 164 and fibroblast growth factor 2 genes for the treatment of horse tendinitis and desmitis: case reports

Kovac, Milomir and Litvin, Yaroslav A. and Aliev, Ruslan O. and Zakirova, Elena Yu and Rutland, Catrin S. and Kiyasov, Andrey and Rizvanov, Albert A. (2017) Gene therapy using plasmid DNA encoding vascular endothelial growth factor 164 and fibroblast growth factor 2 genes for the treatment of horse tendinitis and desmitis: case reports. Frontiers in Veterinary Science, 4 (168). pp. 1-6. ISSN 2297-1769

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Abstract

In this clinical study, for the first time we used the direct gene therapy to restore severe injuries of the suspensory ligament branch and superficial digital flexor tendon in horses (Equus caballus). We injected the plasmid DNA encoding two therapeutic species-specific growth factors: vascular endothelial growth factor 164 and fibroblast growth factor 2 at the site of injury in the suspensory ligament branch and tendon. Treatment effects were evaluated with the use of clinical observation and ultrasound imaging during a period of a few months. We showed that gene therapy used within a period of 2–3 months after the injury resulted in the complete recovery of functions and full restoration of the severely damaged suspensory ligament and superficial digital flexor tendon.

Item Type: Article
Keywords: Gene therapy, Tendon, Suspensory ligament, Horse, Vascular endothelial growth factor, Fibroblast growth factor
Schools/Departments: University of Nottingham, UK > Faculty of Medicine and Health Sciences > School of Veterinary Medicine and Science
Identification Number: 10.3389/fvets.2017.00168
Depositing User: Eprints, Support
Date Deposited: 10 Oct 2017 09:37
Last Modified: 14 Oct 2017 08:48
URI: http://eprints.nottingham.ac.uk/id/eprint/47109

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