Highly efficient oxidation of amines to aldehydes via flow-based biocatalysis

Contente, Martina L. and Dall'Oglio, Federica and Tamborini, Lucia and Molinari, Francesco and Paradisi, Francesca (2017) Highly efficient oxidation of amines to aldehydes via flow-based biocatalysis. Chemcatchem . ISSN 1867-3899

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Abstract

A new mild and efficient process for the preparation of aldehydes in water employed as flavour and fragrance components in food, beverage, cosmetics, as well as in pharmaceuticals was developed using a continuous-flow approach based on an immobilized pure transaminase-packed bed reactor. HEWT, an ω-transaminase from the haloadapted bacterium Halomonas elongata, has been selected for its excellent stability and substrate scope. Sixteen different amines were rapidly (3-15 min) oxidized into the corresponding aldehydes (90 to 99 %) with only 1 to 5 equivalents of sodium pyruvate. The process was fully automated allowing for the in-line recovery of the pure aldehydes (chemical purity >99% and isolated yields above 80%), without any further work-up procedure.

Item Type: Article
Additional Information: This is the peer reviewed version of the following article: ontente, M. L., Dall'Oglio, F., Tamborini, L., Molinari, F. and Paradisi, F. (2017), Highly Efficient Oxidation of Amines to Aldehydes with Flow-based Biocatalysis. ChemCatChem. doi:10.1002/cctc.201701147 which has been published in final form at http://onlinelibrary.wiley.com/doi/10.1002/cctc.201701147/abstract. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving.
Schools/Departments: University of Nottingham, UK > Faculty of Science > School of Chemistry
Identification Number: 10.1002/cctc.201701147
Depositing User: Smith, Ruth
Date Deposited: 05 Oct 2017 12:29
Last Modified: 14 Oct 2017 08:42
URI: http://eprints.nottingham.ac.uk/id/eprint/47020

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