Tuneable 3D printed bioreactors for transaminations under continuous-flow

Peris, Edgar and Okafor, Obinna and Kulchinskaja, Evelina and Goodridge, Ruth D. and Luis, Santiago V. and Garcia-Verdugo, Eduardo and O'Reilly, Elaine and Sans, Victor (2017) Tuneable 3D printed bioreactors for transaminations under continuous-flow. Green Chemistry . ISSN 1463-9270 (In Press)

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Abstract

A method to efficiently immobilize enzymes on 3D printed continuous-flow devices is presented. Application of these chemically modified devices enables rapid screening of immobilization mechanisms and reaction conditions, simple transfer of optimised conditions into tailored printed microfluidic reactors and development of continuous-flow biocatalytic processes. The bioreactors showed good activity (8-20.5 mol h-1mgenz -1) in the kinetic resolution of 1-methylbenzylamine, and very good stability (ca. 100 h under flow).

Item Type: Article
Schools/Departments: University of Nottingham, UK > Faculty of Engineering
University of Nottingham, UK > Faculty of Science > School of Chemistry
Depositing User: Eprints, Support
Date Deposited: 04 Oct 2017 08:58
Last Modified: 14 Oct 2017 08:09
URI: http://eprints.nottingham.ac.uk/id/eprint/46977

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