Facile access to a heterocyclic, sp3-rich chemical scaffold via a tandem condensation/intramolecular nitrone–alkene [3+2] cycloaddition strategy

Rawling, M.J. and Storr, T.E. and Bawazir, W.A. and Cully, S.J. and Lewis, W. and Makki, M.S.I.T. and Strutt, I.R. and Jones, G. and Hamza, D. and Stockman, R.A. (2015) Facile access to a heterocyclic, sp3-rich chemical scaffold via a tandem condensation/intramolecular nitrone–alkene [3+2] cycloaddition strategy. Chemical Communications, 51 (64). pp. 12867-12870. ISSN 1364-548X

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Abstract

A heterocyclic, sp3-rich chemical scaffold was synthesised in just 6 steps via a highly regio- and diastereo-selective tandem nitrone formation/intramolecular nitrone–alkene [3+2] cycloaddition reaction. A library of 543 lead-like compounds based on the scaffold core has been produced.

Item Type: Article
Schools/Departments: University of Nottingham, UK > Faculty of Science > School of Chemistry
Identification Number: 10.1039/c5cc05070g
Depositing User: Lewis, William
Date Deposited: 28 Sep 2017 12:14
Last Modified: 14 Oct 2017 08:32
URI: http://eprints.nottingham.ac.uk/id/eprint/46643

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