Facile access to a heterocyclic, sp3-rich chemical scaffold via a tandem condensation/intramolecular nitrone–alkene [3+2] cycloaddition strategyTools Rawling, M.J. and Storr, T.E. and Bawazir, W.A. and Cully, S.J. and Lewis, W. and Makki, M.S.I.T. and Strutt, I.R. and Jones, G. and Hamza, D. and Stockman, R.A. (2015) Facile access to a heterocyclic, sp3-rich chemical scaffold via a tandem condensation/intramolecular nitrone–alkene [3+2] cycloaddition strategy. Chemical Communications, 51 (64). pp. 12867-12870. ISSN 1364-548X Full text not available from this repository.AbstractA heterocyclic, sp3-rich chemical scaffold was synthesised in just 6 steps via a highly regio- and diastereo-selective tandem nitrone formation/intramolecular nitrone–alkene [3+2] cycloaddition reaction. A library of 543 lead-like compounds based on the scaffold core has been produced.
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