Facile access to a heterocyclic, sp3-rich chemical scaffold via a tandem condensation/intramolecular nitrone–alkene [3+2] cycloaddition strategy

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Rawling, M.J., Storr, T.E., Bawazir, W.A., Cully, S.J., Lewis, W., Makki, M.S.I.T., Strutt, I.R., Jones, G., Hamza, D. and Stockman, R.A. (2015) Facile access to a heterocyclic, sp3-rich chemical scaffold via a tandem condensation/intramolecular nitrone–alkene [3+2] cycloaddition strategy. Chemical Communications, 51 (64). pp. 12867-12870. ISSN 1364-548X

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Abstract

A heterocyclic, sp3-rich chemical scaffold was synthesised in just 6 steps via a highly regio- and diastereo-selective tandem nitrone formation/intramolecular nitrone–alkene [3+2] cycloaddition reaction. A library of 543 lead-like compounds based on the scaffold core has been produced.

Item Type: Article
RIS ID: https://nottingham-repository.worktribe.com/output/757348
Schools/Departments: University of Nottingham, UK > Faculty of Science > School of Chemistry
Identification Number: https://doi.org/10.1039/c5cc05070g
Depositing User: Lewis, William
Date Deposited: 28 Sep 2017 12:14
Last Modified: 04 May 2020 17:13
URI: https://eprints.nottingham.ac.uk/id/eprint/46643

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