A practical and time-efficient high-intensity interval training program modifies cardio-metabolic risk factors in adults with risk factors for type ii diabetes

Phillips, Bethan E. and Kelly, Benjamin M. and Lilja, Mats and Ponce-González, Jesús Gustavo and Brogan, Robert J. and Morris, David L. and Gustafsson, Thomas and Kraus, William E. and Atherton, Philip J. and Vollaard, Niels B. J. and Rooyackers, Olav and Timmons, James A. (2017) A practical and time-efficient high-intensity interval training program modifies cardio-metabolic risk factors in adults with risk factors for type ii diabetes. Frontiers in Endocrinology, 8 . 229/1-229/11. ISSN 1664-2392

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Abstract

Introduction: Regular physical activity (PA) can reduce the risk of developing type 2 diabetes, but adherence to time-orientated (150 min week−1 or more) PA guidelines is very poor. A practical and time-efficient PA regime that was equally efficacious at controlling risk factors for cardio-metabolic disease is one solution to this problem. Herein, we evaluate a new time-efficient and genuinely practical high-intensity interval training (HIT) protocol in men and women with pre-existing risk factors for type 2 diabetes.

Materials and methods: One hundred eighty-nine sedentary women (n = 101) and men (n = 88) with impaired glucose tolerance and/or a body mass index >27 kg m−2 [mean (range) age: 36 (18–53) years] participated in this multi-center study. Each completed a fully supervised 6-week HIT protocol at work-loads equivalent to ~100 or ~125% V˙O2 max. Change in V˙O2 max was used to monitor protocol efficacy, while Actiheart™ monitors were used to determine PA during four, weeklong, periods. Mean arterial (blood) pressure (MAP) and fasting insulin resistance [homeostatic model assessment (HOMA)-IR] represent key health biomarker outcomes.

Results: The higher intensity bouts (~125% V˙O2 max) used during a 5-by-1 min HIT protocol resulted in a robust increase in V˙O2 max (136 participants, +10.0%, p < 0.001; large size effect). 5-by-1 HIT reduced MAP (~3%; p < 0.001) and HOMA-IR (~16%; p < 0.01). Physiological responses were similar in men and women while a sizeable proportion of the training-induced changes in V˙O2 max, MAP, and HOMA-IR was retained 3 weeks after cessation of training. The supervised HIT sessions accounted for the entire quantifiable increase in PA, and this equated to 400 metabolic equivalent (MET) min week−1. Meta-analysis indicated that 5-by-1 HIT matched the efficacy and variability of a time-consuming 30-week PA program on V˙O2 max, MAP, and HOMA-IR.

Conclusion: With a total time-commitment of <15 min per session and reliance on a practical ergometer protocol, 5-by-1 HIT offers a new solution to modulate cardio-metabolic risk factors in adults with pre-existing risk factors for type 2 diabetes while approximately meeting the MET min week−1 PA guidelines. Long-term randomized controlled studies will be required to quantify the ability for 5-by-1 HIT to reduce the incidence of type 2 diabetes, while strategies are required to harmonize the adaptations to exercise across individuals.

Item Type: Article
Keywords: health, exercise, high-intensity interval training, variability, V˙O2 max, blood pressure, detraining, homeostatic model assessment of insulin resistance
Schools/Departments: University of Nottingham, UK > Faculty of Medicine and Health Sciences > School of Medicine > Division of Medical Sciences and Graduate Entry Medicine
Identification Number: 10.3389/fendo.2017.00229
Depositing User: Eprints, Support
Date Deposited: 15 Sep 2017 11:22
Last Modified: 14 Oct 2017 08:09
URI: http://eprints.nottingham.ac.uk/id/eprint/46428

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