Behavioral outcome measures to improve experimental stroke research

Balkaya, Mustafa G. and Trueman, Rebecca C. and Boltze, Johannes and Corbett, Dale and Jolkkonen, Jukka (2017) Behavioral outcome measures to improve experimental stroke research. Behavioural Brain Research . ISSN 1872-7549

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Abstract

Functional recovery after an experimental stroke can be assessed by multiple behavioural tests, however, there is no consensus about which test to use in long-term stroke recovery studies or whether the tests are affected by stroke surgery, post-operative care or behavioural compensation due to repeated testing. This review describes the tests most commonly used to assess motor and sensorimotor function, cognition and mood in stroke animals. Although it is difficult to predict the direction of future research, it may be possible to prevent false-positive results by selecting an appropriate task or a battery of tasks. It is also expected that the upcoming stroke recovery recommendations and the improved dialogue between academy, industry and healthcare professionals will further promote translational success.

Item Type: Article
Keywords: Stroke, Animal models, Behavioral tests, Sensorimotor function, Cognition, Depression, Anxiety, Restoration
Schools/Departments: University of Nottingham, UK > Faculty of Medicine and Health Sciences > School of Life Sciences
Identification Number: 10.1016/j.bbr.2017.07.039
Depositing User: Trueman, Rebecca
Date Deposited: 15 Sep 2017 09:43
Last Modified: 13 Oct 2017 16:36
URI: http://eprints.nottingham.ac.uk/id/eprint/46341

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