High mobility group protein B1 is a predictor of poor survival in ovarian cancer

Machado, Lee R and Moseley, Paul M. and Moss, Robert and Deen, Suha and Nolan, Christopher C. and Spendlove, Ian and Ramage, Judith M. and Chan, Stephen Y.T. and Durrant, Lindy (2017) High mobility group protein B1 is a predictor of poor survival in ovarian cancer. Oncotarget . ISSN 1949-2553

[img]
Preview
PDF - Requires a PDF viewer such as GSview, Xpdf or Adobe Acrobat Reader
Available under Licence Creative Commons Attribution.
Download (2MB) | Preview

Abstract

High-mobility group protein B1 (HMGB1) has been implicated in numerous tumour types where expression regulates tumour cell growth and survival. We hypothesised that high HMGB1 expression in ovarian tumours would predict poor patient survival.

Using tissue microarrays of primary ovarian cancers combined with a comprehensive database of clinicopathological variables, the expression of HMGB1 was assessed by immunohistochemistry in two independent cohorts (n=194 and n=360) using a monoclonal antibody specific for HMGB1.

Kaplan-Meier analysis showed an association of HMGB1 expression with progression free survival in the primary cohort (p=0.023). In the validation cohort, expression was associated with overall survival (p=0.002). Low expression of HMGB1 was protective and in a multivariate model HMGB1 expression was shown to be an independent predictor of poor survival in ovarian cancer (p=0.006).

The role of HMGB1 in cancer is complex. As high levels of HMGB1 expression are likely to render ovarian cancer cells resistant to chemotherapy, therapies targeting the HMGB1 axis may be appropriate in the treatment of ovarian cancer patients

Item Type: Article
Keywords: HMGB1, autophagy, ovarian cancer, prognostic, DAMP
Schools/Departments: University of Nottingham, UK > Faculty of Medicine and Health Sciences > School of Life Sciences > School of Molecular Medical Sciences
University of Nottingham, UK > Faculty of Medicine and Health Sciences > School of Medicine > Division of Child Health, Obstetrics and Gynaecology
University of Nottingham, UK > Faculty of Medicine and Health Sciences > School of Medicine > Division of Cancer and Stem Cells
Identification Number: 10.18632/oncotarget.20538
Depositing User: Ramage, Judith
Date Deposited: 31 Aug 2017 12:20
Last Modified: 31 Aug 2017 13:29
URI: http://eprints.nottingham.ac.uk/id/eprint/45301

Actions (Archive Staff Only)

Edit View Edit View