Effect of delivery method on the efficacy of Salmonella vaccination in chickens

Atterbury, Robert J., Morris, V., Harrison, D., Tucker, V., Allen, V.M., Davies, R.H. and Carrique-Mas, J.J. (2010) Effect of delivery method on the efficacy of Salmonella vaccination in chickens. Veterinary Record, 167 (5). pp. 161-164. ISSN 2042-7670

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To investigate whether the efficacy of live vaccines is influenced by the mode of vaccine delivery, a widely-used UK live commercial Salmonella Enteritidis vaccine was delivered to pullet chicks either by spray, in drinking water, or in combination with a bivalent vaccine containing inactivated Salmonella Enteritidis and Salmonella Typhimurium. The birds were subsequently challenged with 102 or 108 colony-forming units (cfu) of Salmonella Enteritidis through drinking water at either six or 20 weeks of age. Ten days after the challenge, the birds were euthanased and their caecal contents cultured for Salmonella. All of the vaccinated groups contained fewer Salmonella Enteritidis-positive birds than the unvaccinated groups. The ‘spray-vaccinated’ group contained significantly fewer Salmonella Enteritidis-positive birds than the ‘water-vaccinated’ group after challenge with 108 cfu at 20 weeks. However, there was little or no difference at the other challenge time points between the groups that received vaccine through different modes of delivery.

Item Type: Article
RIS ID: https://nottingham-repository.worktribe.com/output/1011884
Schools/Departments: University of Nottingham, UK > Faculty of Medicine and Health Sciences > School of Veterinary Medicine and Science
Identification Number: https://doi.org/10.1136/vr.b4884
Depositing User: Eprints, Support
Date Deposited: 30 Aug 2017 10:37
Last Modified: 04 May 2020 20:24
URI: https://eprints.nottingham.ac.uk/id/eprint/45240

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