All-cause mortality in people with cirrhosis compared with the general population: a population-based cohort study

Fleming, Kate M. and Aithal, Guruprasad P. and Card, Tim R. and West, Joe (2012) All-cause mortality in people with cirrhosis compared with the general population: a population-based cohort study. Liver International, 32 (1). pp. 79-84. ISSN 1478-3231

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Abstract

Background: Mortality due to cirrhosis has tripled over the last 30 years in the UK. However, we lack adequate, contemporary, population-based estimates of the excess mortality patients who are at risk compared with the general population.

Aim: To determine the overall survival in patients with cirrhosis compared with the general population taking into account the effects of severity and aetiology of disease and comorbidity.

Methods: In a cohort study, we identified 4537 people with cirrhosis and a control cohort of 44 403 patients, matched by age, sex and general practice from the UK General Practice Research Database between June 1987 and April 2002.

Results: Patients with compensated cirrhosis had a nearly five-fold [hazard ratio (HR) 4.7, 95% confidence interval (CI) 4.4–5.0] increased risk of death, while those with decompensated cirrhosis had a near 10-fold (HR 9.7, 95% CI 8.9–10.6) increased risk compared with the general population. Alcoholic cirrhosis conferred a worse prognosis than non-alcohol-related cirrhosis both in the first year following diagnosis and subsequently.

Conclusion: Having a diagnosis of cirrhosis confers a substantial increased mortality risk compared with the general population, even for those with compensated disease, with 5-year survival between that seen for breast and colorectal cancer.

Item Type: Article
Schools/Departments: University of Nottingham, UK > Faculty of Medicine and Health Sciences > School of Medicine > Division of Epidemiology and Public Health
University of Nottingham, UK > Faculty of Medicine and Health Sciences > School of Medicine > Nottingham Digestive Diseases Centre
Identification Number: 10.1111/j.1478-3231.2011.02517.x
Depositing User: Eprints, Support
Date Deposited: 24 Aug 2017 10:43
Last Modified: 20 Nov 2017 21:00
URI: http://eprints.nottingham.ac.uk/id/eprint/45119

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