Contribution of flagella and motility to gut colonisation and pathogenicity of Salmonella Enteritidis in the chicken

Barbosa, Fernanda de Oliveira and Freitas Neto, Oliveiro Caetano de and Batista, Diego Felipe Alves and Almeida, Adriana Maria de and Rubio, Marcela da Silva and Alves, Lucas Bocchini Rodrigues and Vasconcelos, Rosemeire de Oliveira and Barrow, Paul Andrew and Berchieri Junior, Angelo (2017) Contribution of flagella and motility to gut colonisation and pathogenicity of Salmonella Enteritidis in the chicken. Brazilian Journal of Microbiology . ISSN 1517-8382

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Abstract

Salmonella Enteritidis causes fowl paratyphoid in poultry and is frequently associated to outbreaks of food-borne diseases in humans. The role of flagella and flagella-mediated motility into host-pathogen interplay is not fully understood and requires further investigation. In this study, one-day-old chickens were challenged orally with a wild-type strain Salmonella Enteritidis, a non-motile but fully flagellated (SE ΔmotB) or non-flagellated (SE ΔfliC) strain to evaluate their ability to colonise the intestine and spread systemically and also of eliciting gross and histopathological changes. SE ΔmotB and SE ΔfliC were recovered in significantly lower numbers from caecal contents in comparison with Salmonella Enteritidis at early stages of infection (3 and 5 dpi). The SE ΔmotB strain, which synthesises paralysed flagella, showed poorer intestinal colonisation ability than the non-flagellated SE ΔfliC. Histopathological analyses demonstrated that the flagellated strains induced more intense lymphoid reactivity in liver, ileum and caeca. Thus, in the present study the flagellar structure and motility seemed to play a role in the early stages of the intestinal colonisation by Salmonella Enteritidis in the chicken.

Item Type: Article
RIS ID: https://nottingham-repository.worktribe.com/output/864522
Keywords: Mutation ; Flagellum ; Virulence factors ; Poultry ; Gut colonisation
Schools/Departments: University of Nottingham, UK > Faculty of Medicine and Health Sciences > School of Veterinary Medicine and Science
Identification Number: https://doi.org/10.1016/j.bjm.2017.01.012
Depositing User: Eprints, Support
Date Deposited: 23 Aug 2017 11:00
Last Modified: 04 May 2020 18:48
URI: http://eprints.nottingham.ac.uk/id/eprint/45100

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