Functionalisation of Ti6Al4V components fabricated using selective laser melting with a bioactive compound

Vaithilingam, Jayasheelan and Kilsby, Samuel and Goodridge, Ruth D. and Christie, Steven D.R. and Edmondson, Steve and Hague, Richard J.M. (2015) Functionalisation of Ti6Al4V components fabricated using selective laser melting with a bioactive compound. Materials Science and Engineering: C, 46 . pp. 52-61. ISSN 0928-4931

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Abstract

Surface modification of an implant with a biomolecule is used to improve its biocompatibility and to reduce post-implant complications. In this study, a novel approach has been used to functionalise phosphonic acid monolayers with a drug. Ti6Al4V components fabricated using selective laser melting (SLM) were functionalised with Paracetamol (a pharmaceutically relevant biomolecule) using phosphonic acid based self-assembled monolayers (SAMs). The attachment, stability of the monolayers on the SLM fabricated surface and functionalisation of SAMs with Paracetamol were studied using X-ray photoelectron spectroscopy (XPS) and surface wettability measurements. The obtained results confirmed that SAMs were stable on the Ti6Al4V surface for over four weeks and then began to desorb from the surface. The reaction used to functionalise the phosphonic acid monolayers with Paracetamol was noted to be successful. Thus, the proposed method has the potential to immobilise drugs/proteins to SAM coated surfaces and improve their biocompatibility and reduce post-implant complications.

Item Type: Article
Keywords: Selective laser melting (SLM), Self-assembled monolayers (SAMs), Additive manufacturing Functionalisation, X-ray photoelectron spectroscopy (XPS)
Schools/Departments: University of Nottingham, UK > Faculty of Engineering > Department of Mechanical, Materials and Manufacturing Engineering
Identification Number: 10.1016/j.msec.2014.10.015
Depositing User: Eprints, Support
Date Deposited: 08 Aug 2017 09:49
Last Modified: 16 Oct 2017 01:21
URI: http://eprints.nottingham.ac.uk/id/eprint/44743

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