Gene × environment interactions in schizophrenia: evidence from genetic mouse models

Moran, Paula M. and Stokes, Jennifer and Marr, Julia and Bock, Gavin and Desbonnet, Lieve and Waddington, J.L. and O'Tuathaigh, C.M.P. (2016) Gene × environment interactions in schizophrenia: evidence from genetic mouse models. Neural Plasticity, 2016 . 2173748/1- 2173748/23. ISSN 1687-5443

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Abstract

The study of gene × environment, as well as epistatic interactions in schizophrenia, has provided important insight into the complex etiopathologic basis of schizophrenia. It has also increased our understanding of the role of susceptibility genes in the disorder and is an important consideration as we seek to translate genetic advances into novel antipsychotic treatment targets. This review summarises data arising from research involving the modelling of gene × environment interactions in schizophrenia using preclinical genetic models. Evidence for synergistic effects on the expression of schizophrenia-relevant endophenotypes will be discussed. It is proposed that valid and multifactorial preclinical models are important tools for identifying critical areas, as well as underlying mechanisms, of convergence of genetic and environmental risk factors, and their interaction in schizophrenia.

Item Type: Article
Schools/Departments: University of Nottingham, UK > Faculty of Science > School of Psychology
Identification Number: 10.1155/2016/2173748
Depositing User: Moran, Paula
Date Deposited: 31 Jul 2017 08:06
Last Modified: 12 Oct 2017 23:31
URI: http://eprints.nottingham.ac.uk/id/eprint/44495

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