Long-term coding of personal and universal associations underlying the memory web in the human brain

De Falco, Emanuela and Ison, Matias J. and Fried, Itzhak and Quian Quiroga, Rodrigo (2016) Long-term coding of personal and universal associations underlying the memory web in the human brain. Nature Communications, 7 . 13408/1-13408/11. ISSN 2041-1723

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Abstract

Neurons in the medial temporal lobe (MTL), a critical area for declarative memory, have been shown to change their tuning in associative learning tasks. Yet, it is unclear how durable these neuronal representations are and if they outlast the execution of the task. To address this issue, we studied the responses of MTL neurons in neurosurgical patients to known concepts (people and places). Using association scores provided by the patients and a web-based metric, here we show that whenever MTL neurons respond to more than one concept, these concepts are typically related. Furthermore, the degree of association between concepts could be successfully predicted based on the neurons’ response patterns. These results provide evidence for a long-term involvement of MTL neurons in the representation of durable associations, a hallmark of human declarative memory.

Item Type: Article
Schools/Departments: University of Nottingham, UK > Faculty of Science > School of Psychology
Identification Number: 10.1038/ncomms13408
Depositing User: Ison, Matias
Date Deposited: 31 Jul 2017 07:20
Last Modified: 12 Oct 2017 23:30
URI: http://eprints.nottingham.ac.uk/id/eprint/44487

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