The heritability of multi-modal connectivity in human brain activity

Colclough, Giles L. and Smith, Stephen M. and Nichols, Tom E. and Winkler, Anderson M. and Sotiropoulos, Stamatios N. and Glasser, Matthew F. and Van Essen, David C. and Woolrich, Mark W. (2017) The heritability of multi-modal connectivity in human brain activity. eLife, 6 . e20178. ISSN 2050-084X (In Press)

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Abstract

Patterns of intrinsic human brain activity exhibit a profile of functional connectivity that is associated with behaviour and cognitive performance, and deteriorates with disease. This paper investigates the relative importance of genetic factors and the common environment between twins in determining this functional connectivity profile. Using functional magnetic resonance imaging (fMRI) on 820 subjects from the Human Connectome Project, and magnetoencephalographic (MEG) recordings from a subset, the heritability of connectivity between 39 cortical regions was estimated. On average over all connections, genes account for about 15% of the observed variance in fMRI connectivity (and about 10% in alpha-band and 20% in beta-band oscillatory power synchronisation), which substantially exceeds the contribution from the environment shared between twins. Therefore, insofar as twins share a common upbringing, it appears that genes, rather than the developmental environment, play a dominant role in determining the coupling of neuronal activity.

Item Type: Article
Schools/Departments: University of Nottingham, UK > Faculty of Medicine and Health Sciences > School of Medicine
Identification Number: 10.7554/eLife.20178
Depositing User: Eprints, Support
Date Deposited: 27 Jul 2017 10:22
Last Modified: 12 Oct 2017 23:29
URI: http://eprints.nottingham.ac.uk/id/eprint/44464

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