3D printing of tablets using inkjet with UV photoinitiation

Clark, Elizabeth A. and Alexander, Morgan R. and Irvine, Derek J. and Roberts, Clive J. and Wallace, Martin J. and Sharpe, Sonja and Yoo, Jae and Hague, Richard J.M. and Tuck, Chris J. and Wildman, Ricky D. (2017) 3D printing of tablets using inkjet with UV photoinitiation. International Journal of Pharmaceutics . ISSN 0378-5173

[img] PDF - Repository staff only until 30 June 2018. - Requires a PDF viewer such as GSview, Xpdf or Adobe Acrobat Reader
Available under Licence Creative Commons Attribution Non-commercial No Derivatives.
Download (442kB)

Abstract

Additive manufacturing (AM) offers significant potential benefits in the field of drug delivery and pharmaceutical/medical device manufacture. Of AM processes, 3D inkjet printing enables precise deposition of a formulation, whilst offering the potential for significant scale up or scale out as a manufacturing platform. This work hypothesizes that suitable solvent based ink formulations can be developed that allow the production of solid dosage forms that meet the standards required for pharmaceutical tablets, whilst offering a platform for flexible and personalised manufacture. We demonstrate this using piezo-activated inkjetting to 3D print ropinirole hydrochloride. The tablets produced consist of a cross-linked poly(ethylene glycol diacrylate) (PEGDA) hydrogel matrix containing the drug, photoinitiated in a low oxygen environment using an aqueous solution of Irgacure 2959. At a Ropinirole HCl loading of 0.41 mg, drug release from the tablet is shown to be Fickian. Raman and IR spectroscopy indicate a high degree of cross-linking and formation of an amorphous solid dispersion. This is the first publication of a UV inkjet 3D printed tablet. Consequently, this work opens the possibility for the translation of scalable, high precision and bespoke ink-jet based additive manufacturing to the pharmaceutical sector.

Item Type: Article
Schools/Departments: University of Nottingham, UK > Faculty of Engineering
University of Nottingham, UK > Faculty of Science > School of Pharmacy
Identification Number: 10.1016/j.ijpharm.2017.06.085
Depositing User: Eprints, Support
Date Deposited: 27 Jul 2017 09:54
Last Modified: 27 Jul 2017 10:53
URI: http://eprints.nottingham.ac.uk/id/eprint/44460

Actions (Archive Staff Only)

Edit View Edit View