The natural history of subjective tinnitus in adults: a systematic review and meta-analysis of ‘no-intervention’ periods in controlled trials

Phillips, John and McFerran, Don and Hall, Deborah A. and Hoare, Derek J. (2017) The natural history of subjective tinnitus in adults: a systematic review and meta-analysis of ‘no-intervention’ periods in controlled trials. Laryngoscope . ISSN 1531-4995

[img] PDF - Repository staff only until 20 April 2018. - Requires a PDF viewer such as GSview, Xpdf or Adobe Acrobat Reader
Download (692kB)

Abstract

Objectives

Tinnitus is a prevalent condition, but little has been published regarding the natural history of the condition. One technique for evaluating the long-term progression of the disease is to examine what happens to participants in the no-intervention control arm of a clinical trial. The aim of this study was to examine no-intervention or waiting-list data reported in trials, in which participants on the active arm received any form of tinnitus intervention.

Data Sources

CINAHL, PsychINFO, EMBASE, ASSIA, PubMed, Web of Science, Science Direct, EBSCO Host, and Cochrane.

Methods

Inclusion criteria followed the PICOS principles: Participants, adults with tinnitus; Intervention, none; Control, any intervention for alleviating tinnitus; Outcomes, a measure assessing tinnitus symptoms using a multi-item patient-reported tinnitus questionnaire. Secondary outcome measures included multi-item patient-reported questionnaires of mood and health-related quality of life and measures that quantified change in tinnitus loudness; Study design, randomized controlled trials or observational studies utilizing a no-intervention or waiting-list control group. Data were extracted and standardized mean difference was calculated for each study to enable meta-analysis.

Results

The evidence strongly favored a statistically significant decrease in the impact of tinnitus over time, though there was significant heterogeneity and clinical significance cannot be interpreted. Outcome data regarding secondary measures did not demonstrate any clinically significant change.

Conclusions

Participants allocated to the no-intervention or waiting-list control arm of clinical trials for a tinnitus intervention show a small but significant improvement in self-reported measures of tinnitus with time; the clinical significance of this finding is unknown. There is, however, considerable variation across individuals. These findings support previous work and can cautiously be used when counseling patients.

Item Type: Article
Keywords: Tinnitus; natural history; outcomes; control; waiting list
Schools/Departments: University of Nottingham, UK > Faculty of Medicine and Health Sciences > School of Medicine > Division of Clinical Neuroscience
Identification Number: 10.1002/lary.26607
Depositing User: Hoare, Derek
Date Deposited: 21 Jul 2017 11:45
Last Modified: 21 Jul 2017 11:51
URI: http://eprints.nottingham.ac.uk/id/eprint/44352

Actions (Archive Staff Only)

Edit View Edit View