Born from pre-eclamptic pregnancies predisposes infants to altered cortisol metabolism in the first postnatal year

Broughton Pipkin, Fiona and Mistry, Hiten D. and Roy, Chandrima and Dick, Bernhard and Waugh, Jason and Chikhi, Rebecca and Kurlak, L.O. and Mohaupt, Markus (2015) Born from pre-eclamptic pregnancies predisposes infants to altered cortisol metabolism in the first postnatal year. Endcrine Connections, 4 (4). pp. 233-241. ISSN 2049-3614

[img]
Preview
PDF - Requires a PDF viewer such as GSview, Xpdf or Adobe Acrobat Reader
Available under Licence Creative Commons Attribution.
Download (325kB) | Preview

Abstract

Pre-eclampsia leads to disturbed fetal organ development, including metabolic syndrome, attributed to altered pituitary-adrenal feedback loop. We measured cortisol metabolites in infants born from pre-eclamptic and normotensive women and hypothesised that glucocorticoid exposure would be exaggerated in the former. Twenty-four hour urine was collected from infants at months 3 and 12. Cortisol metabolites and apparent enzyme activities were analysed by gas chromatography-mass spectrometry. From 3 to 12 months, excretion of THS, THF and pregnandiol had risen in both groups; THF also rose in the pre-eclamptic group. No difference was observed with respect to timing of the visit or to hypertensive status for THE or total F metabolites (P>0.05). All apparent enzymes activities, except 17α-hydroxylase, were lower in infants at 12 compared to 3 months in the normotensive group. In the pre-eclamptic group, only 11β-HSD activities were lower at 12 months.17α-hydroxylase and 11β-HSD activities of tetrahydro metabolites were higher in the pre-eclamptic group at 3 months (P<0.05). 11β-hydroxylase activity increased in the pre-eclamptic group at 12 months. Cortisol excretion, determined by increased 11β-hydroxylase, compensates for high 11β-HSD-dependent cortisol degradation at 3 months and at 12 months counterbalances the reduced cortisol substrate availability in infants born from pre-eclamptic mothers.

Item Type: Article
Keywords: steroid hormones; pre-eclampsia; infants; urine
Schools/Departments: University of Nottingham, UK > Faculty of Medicine and Health Sciences > School of Medicine > Division of Child Health, Obstetrics and Gynaecology
Identification Number: 10.1530/EC-15-0084
Depositing User: Mistry, Hiten
Date Deposited: 21 Jul 2017 10:28
Last Modified: 12 Oct 2017 23:35
URI: http://eprints.nottingham.ac.uk/id/eprint/44332

Actions (Archive Staff Only)

Edit View Edit View