Placental expression of eNOS, iNOS and the major protein components of caveolae in women with pre-eclampsia

Smith-Jackson, Kate and Hentschke, Marta and Poli-de-Figueiredo, Carlos and Pinheiro da Costa, Bartira and Broughton Pipkin, Fiona and Czajka, Anna and Mistry, Hiten D. (2015) Placental expression of eNOS, iNOS and the major protein components of caveolae in women with pre-eclampsia. Placenta, 36 (5). pp. 607-610. ISSN 1532-3102

[img]
Preview
PDF - Requires a PDF viewer such as GSview, Xpdf or Adobe Acrobat Reader
Available under Licence Creative Commons Attribution Non-commercial No Derivatives.
Download (334kB) | Preview

Abstract

Caveolae regulate many cardiovascular functions and thus could be of interest in relation to pre-eclampsia, a pregnancy specific disorder characterised by hypertension and proteinuria. We examined placental mRNA and protein expression/localisation of the caveolae components Caveolin 1-3, Cavin 1-4 as well as eNOS/ iNOS in normotensive control (n=24) and pre-eclamptic pregnancies (n=19). Placental mRNA expression of caveolin-1, cavin 1-3, was lower and eNOS expression was increased in pre-eclampsia (P<0.05 for all). Additionally Caveolin-1 protein expression was also reduced in pre-eclampsia (P=0.007); this could be an adaptive response in pre-eclampsia, possibly to attenuate the oxidative stress/inflammation.

Item Type: Article
Keywords: Hypertension; Cavin; Caveolin; Pre-eclampsia; Placenta
Schools/Departments: University of Nottingham, UK > Faculty of Medicine and Health Sciences > School of Medicine > Division of Child Health, Obstetrics and Gynaecology
Identification Number: 10.1016/j.placenta.2015.02.001
Depositing User: Mistry, Hiten
Date Deposited: 21 Jul 2017 10:11
Last Modified: 21 Jul 2017 10:17
URI: http://eprints.nottingham.ac.uk/id/eprint/44328

Actions (Archive Staff Only)

Edit View Edit View