Placental expression of eNOS, iNOS and the major protein components of caveolae in women with pre-eclampsiaTools Smith-Jackson, Kate and Hentschke, Marta and Poli-de-Figueiredo, Carlos and Pinheiro da Costa, Bartira and Broughton Pipkin, Fiona and Czajka, Anna and Mistry, Hiten D. (2015) Placental expression of eNOS, iNOS and the major protein components of caveolae in women with pre-eclampsia. Placenta, 36 (5). pp. 607-610. ISSN 1532-3102
AbstractCaveolae regulate many cardiovascular functions and thus could be of interest in relation to pre-eclampsia, a pregnancy specific disorder characterised by hypertension and proteinuria. We examined placental mRNA and protein expression/localisation of the caveolae components Caveolin 1-3, Cavin 1-4 as well as eNOS/ iNOS in normotensive control (n=24) and pre-eclamptic pregnancies (n=19). Placental mRNA expression of caveolin-1, cavin 1-3, was lower and eNOS expression was increased in pre-eclampsia (P<0.05 for all). Additionally Caveolin-1 protein expression was also reduced in pre-eclampsia (P=0.007); this could be an adaptive response in pre-eclampsia, possibly to attenuate the oxidative stress/inflammation.
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