Expression of voltage-dependent potassium channels in first trimester human placentae

Mistry, Hiten D. and Kurlak, L.O. and Whitley, Guy S. and Cartwright, Judith E. and Broughton Pipkin, Fiona and Tribe, Rachel M. (2014) Expression of voltage-dependent potassium channels in first trimester human placentae. Placenta, 35 (5). pp. 337-340. ISSN 1532-3102

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Abstract

Potassium channel α-subunits encoded by KCNQ1-5 genes form voltage-dependent channels (Kv7), modulated by KCNE1-5 encoded accessory proteins. The aim was to determine KCNQ and KCNE mRNA expression and assess protein expression/localisation of the KCNQ3 and KCNE5 isoforms in first trimester placental tissue. Placentae were obtained from women undergoing elective surgical termination of pregnancy (TOP) at <10 weeks’ (early TOP) and >10 weeks’ (mid TOP) gestations. KCNQ1-5 expression was unchanged during the first trimester. KCNE5 expression increased in mid TOP vs. early TOP samples (P=0.022). This novel study reports mRNA and protein expression of Kv7 channels in first trimester placentae.

Item Type: Article
Keywords: Potassium channel, Placenta, Early pregnancy, KCNQ, KCNE
Schools/Departments: University of Nottingham, UK > Faculty of Medicine and Health Sciences > School of Medicine > Division of Child Health, Obstetrics and Gynaecology
Identification Number: 10.1016/j.placenta.2014.02.008
Depositing User: Mistry, Hiten
Date Deposited: 21 Jul 2017 10:02
Last Modified: 12 Oct 2017 23:34
URI: http://eprints.nottingham.ac.uk/id/eprint/44325

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