Priorities for research in miscarriage: a priority setting partnership between people affected by miscarriage and professionals, following the James Lind Alliance methodology

Prior, Matthew and Bagness, Carmel and Brewin, Jane and Coomarasamy, Arri and Easthope, Lucy and Hepworth-Jones, Barbara and Hinshaw, Kim and O'Toole, Emily and Orford, Julie and Regan, Lesley and Raine-Fenning, Nick and Shakespeare, Judy and Small, Rachel and Thornton, Jim and Metcalf, Leanne (2017) Priorities for research in miscarriage: a priority setting partnership between people affected by miscarriage and professionals, following the James Lind Alliance methodology. BMJ Open, 7 . e016571. ISSN 2044-6055

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Abstract

Objectives: To identify and prioritise important research questions for miscarriage.

Design: A priority setting partnership using prospective surveys and consensus meetings following methods advocated by the James Lind Alliance.

Setting: United Kingdom

Participants: Women and those affected by miscarriage working alongside healthcare professionals.

Results: In the initial survey, 1093 participants (932 women who have experienced miscarriage, 8 partners, 17 family members, friends or colleagues, 104 HCPs and 8 charitable organisations) submitted 3279 questions. A review of existing literature identified a further 64. Non-questions were removed and the remaining questions were categorised and summarised into 58 questions. In an interim electronic survey 2122 respondents chose their top ten priorities from the 58 summary questions. The 25 highest ranked in the survey were prioritised at a final face-to-face workshop. In summary, the top ten priorities were ranked as follows: research into preventative treatment, emotional aspects in general, investigation, relevance of pre-existing medical conditions, emotional support as a treatment, importance of lifestyle factors, importance of genetic and chromosomal causes, preconception tests, investigation after different numbers of miscarriage and male causal factors.

Conclusions: These results should be the focus of future miscarriage research. Presently, studies are being conducted to address the top priority, however many other priorities, especially psychological and emotional support are less well researched areas. We hope our results will encourage both researchers and funders to focus on these priorities.

Item Type: Article
Keywords: Reproductive medicine, Qualitative research, Statistics & research methods, Ultrasound, Depression & mood disorders
Schools/Departments: University of Nottingham, UK > Faculty of Medicine and Health Sciences > School of Medicine > Division of Child Health, Obstetrics and Gynaecology
Identification Number: 10.1136/bmjopen-2017-016571
Depositing User: Eprints, Support
Date Deposited: 13 Jul 2017 07:54
Last Modified: 14 Dec 2017 10:38
URI: http://eprints.nottingham.ac.uk/id/eprint/44144

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