Total synthesis of the cyclic dodecapeptides wewakazole and wewakazole B

Inman, Martyn, Dexter, Hannah L. and Moody, Christopher J. (2017) Total synthesis of the cyclic dodecapeptides wewakazole and wewakazole B. Organic Letters, 19 (13). pp. 3454-3457. ISSN 1523-7052

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Abstract

The cyclic dodecapeptides wewakazole and wewakazole B have been synthesized by a divergent strategy via a common tris-proline containing oxazole octapeptide and two separate bisoxazole containing tetrapeptide units, followed by peptide coupling and macrocyclization. The three oxazole amino acid fragments are readily accessible by rhodium(II)-catalysed amide N–H insertion of diazocarbonyl compounds, or by the cycloaddition of rhodium carbenoids with nitriles.

Item Type: Article
RIS ID: https://nottingham-repository.worktribe.com/output/865884
Schools/Departments: University of Nottingham, UK > Faculty of Science > School of Chemistry
Identification Number: https://doi.org/10.1021/acs.orglett.7b01393
Depositing User: Smith, Ruth
Date Deposited: 11 Jul 2017 13:29
Last Modified: 04 May 2020 18:49
URI: https://eprints.nottingham.ac.uk/id/eprint/44072

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