Comparative virus replication and host innate responses in human cells infected with three prevalent clades (2.3.4, 2.3.2, and 7) of highly pathogenic avian influenza H5N1 viruses

Sun, H. and Sun, Y. and Pu, J. and Zhang, Y. and Zhu, Q. and Li, J. and Gu, J. and Chang, K.-C. and Liu, J. (2014) Comparative virus replication and host innate responses in human cells infected with three prevalent clades (2.3.4, 2.3.2, and 7) of highly pathogenic avian influenza H5N1 viruses. Journal of Virology, 88 (1). pp. 725-729. ISSN 0022-538X

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Abstract

Highly pathogenic avian influenza H5N1 virus clades 2.3.4, 2.3.2, and 7 are the dominant cocirculating H5N1 viruses in poultry in China. However, humans appear to be clinically susceptible mostly to the 2.3.4 virus clade. Here, we demonstrated that A549 cells and human macrophages infected with clade 2.3.4 viruses produced significantly more viruses than those infected with the other two clades. Likewise, clade 2.3.4-infected macrophages caused the most severe cellular damage and strongest proinflammatory response.

Item Type: Article
Schools/Departments: University of Nottingham, UK > Faculty of Medicine and Health Sciences > School of Veterinary Medicine and Science
Identification Number: 10.1128/JVI.02510-13
Depositing User: Eprints, Support
Date Deposited: 30 Jun 2017 14:07
Last Modified: 02 Jul 2017 04:19
URI: http://eprints.nottingham.ac.uk/id/eprint/43921

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