Translational considerations in injectable cell-based therapeutics for neurological applications: concepts, progress and challenges

Amer, Mahetab H. and Rose, Felicity R.A.J. and Shakesheff, Kevin M. and Modo, Michel and White, Lisa J. (2017) Translational considerations in injectable cell-based therapeutics for neurological applications: concepts, progress and challenges. npj Regenerative Medicine, 2 . 23/1-23/13. ISSN 2057-3995

[img]
Preview
PDF - Requires a PDF viewer such as GSview, Xpdf or Adobe Acrobat Reader
Available under Licence Creative Commons Attribution.
Download (1MB) | Preview
[img] PDF - Repository staff only - Requires a PDF viewer such as GSview, Xpdf or Adobe Acrobat Reader
Download (611kB)

Abstract

Significant progress has been made during the past decade towards the clinical adoption of cell- based therapeutics. However, existing cell delivery approaches have shown limited success, with numerous studies showing fewer than 5% of injected cells persisting at the site of injection within days of transplantation. Although consideration is being increasingly given to clinical trial design, little emphasis has been given to tools and protocols used to administer cells. The different behaviours of various cell types, dosing accuracy, precise delivery, and cell retention and viability post-injection are some of the obstacles facing clinical translation. For efficient injectable cell transplantation, accurate characterisation of cellular health post-injection and the development of standardised administration protocols are required. This review provides an overview of the challenges facing effective delivery of cell therapies, examines key studies that have been carried out to investigate injectable cell delivery, and outlines opportunities for translating these findings into more effective cell therapy interventions.

Item Type: Article
Keywords: Injectable cell therapy, cell delivery, cell injection, needles, syringe, viability
Schools/Departments: University of Nottingham, UK > Faculty of Science > School of Pharmacy
Identification Number: 10.1038/s41536-017-0028-x
Depositing User: Eprints, Support
Date Deposited: 15 Aug 2017 10:09
Last Modified: 19 Nov 2017 17:59
URI: http://eprints.nottingham.ac.uk/id/eprint/43700

Actions (Archive Staff Only)

Edit View Edit View