Translating advances in the molecular basis of schizophrenia into novel cognitive treatment strategies

O'Tuathaigh, C.M.P. and Moran, P.M. and Zhen, X.C. and Waddington, J.L. (2017) Translating advances in the molecular basis of schizophrenia into novel cognitive treatment strategies. British Journal of Pharmacology . ISSN 1476-5381

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Abstract

The presence and severity of cognitive symptoms, including working memory, executive dysfunction and attentional impairment, contributes materially to functional impairment in schizophrenia. Cognitive symptoms have proven resistant to both first- and second-generation antipsychotic drugs. Efforts to develop a consensus set of cognitive domains that are both disrupted in schizophrenia and are amenable to cross-species validation (e.g. the NIMH CNTRICS and RDoC initiatives) are an important step towards standardisation of outcome measures that can used in preclinical testing of new drugs. While causative genetic mutations have not been identified, new technologies have identified novel genes as well as hitherto candidate genes previously implicated in the pathophysiology of schizophrenia and/or mechanisms of antipsychotic efficacy. This review comprises a selective summary of these developments, particularly phenotypic data arising from preclinical genetic models for cognitive dysfunction in schizophrenia, with the aim of indicating potential new directions for pro-cognitive therapeutics.

Item Type: Article
Additional Information: This is the peer reviewed version of the following article: O'Tuathaigh, C. M. P., Moran, P. M., Zhen, X. C., and Waddington, J. L. (2017) Translating advances in the molecular basis of schizophrenia into novel cognitive treatment strategies. British Journal of Pharmacology, doi: 10.1111/bph.13938 which has been published in final form at http://onlinelibrary.wiley.com/doi/10.1111/bph.13938/full This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving.
Schools/Departments: University of Nottingham, UK > Faculty of Science > School of Psychology
Identification Number: 10.1111/bph.13938
Depositing User: Moran, Paula
Date Deposited: 21 Jun 2017 11:22
Last Modified: 07 Aug 2017 10:18
URI: http://eprints.nottingham.ac.uk/id/eprint/43662

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