3D microfabricated scaffolds and microfluidic devices for ocular surface replacement: a review

Prina, Elisabetta and Mistry, Pritesh and Sidney, Laura E. and Yang, Jing and Wildman, Ricky D. and Bertolin, Marina and Breda, Claudia and Ferrari, Barbara and Barbaro, Vanessa and Hopkinson, Andrew and Dua, Harminder S. and Ferrari, Stefano and Rose, Felicity R A.J. (2017) 3D microfabricated scaffolds and microfluidic devices for ocular surface replacement: a review. Stem Cell Reviews and Reports . ISSN 1558-6804

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Abstract

In recent years, there has been increased research interest in generating corneal substitutes, either for use in the clinic or as in vitro corneal models. The advancement of 3D microfabrication technologies has allowed the reconstruction of the native microarchitecture that controls epithelial cell adhesion, migration and differentiation. In addition, such technology has allowed the inclusion of a dynamic fluid flow that better mimics the physiology of the native cornea. We review the latest innovative products in development in this field, from 3D microfabricated hydrogels to microfluidic devices.

Item Type: Article
Additional Information: The final publication is available at Springer via http://dx.doi.org/10.1007/s12015-017-9740-6.
Keywords: Cornea, topography, microfabrication, 3D model, microfluidics
Schools/Departments: University of Nottingham, UK > Faculty of Science > School of Pharmacy
Identification Number: 10.1007/s12015-017-9740-6
Depositing User: Eprints, Support
Date Deposited: 12 Jun 2017 13:51
Last Modified: 12 Oct 2017 22:53
URI: http://eprints.nottingham.ac.uk/id/eprint/43513

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