Hypophysitis, panhypopituitarism, and hypothalamitis in a Scottish terrier dog

Polledo, L. and Oliveira, M. and Adamany, J. and Graham, P. and Baiker, Kerstin (2017) Hypophysitis, panhypopituitarism, and hypothalamitis in a Scottish terrier dog. Journal of Veterinary Internal Medicine, 31 (5). pp. 1257-1532. ISSN 1939-1676

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Abstract

A 6-year old male neutered Scottish Terrier was referred with a 1 week history of progressive lethargy and anorexia. Neurological examination localized a lesion to the forebrain and hormonal testing showed panhypopituitarism. Magnetic resonance imaging (MRI) of the brain revealed a rounded, well-defined, suprasellar central mass. The mass was slightly hyperintense to the cortical grey matter on T2-weighted (T2W), hypointense on T1-weighted (T1W) images and without T2* signal void. There was a central fusiform enhancement of the mass after contrast administration which raised the suspicion of a pituitary neoplasm. Rapid deterioration of the dog prevented further clinical investigations. Histopathologic examination revealed a lymphocytic panhypophysitis of unknown origin suspected autoimmune involving the hypothalamus (hypothalamitis). This is a unique case report of a dog presenting with inflammatory hypophysitis and hypothalamitis of suspected autoimmune origin with detailed clinical, MRI, histology and immunohistochemistry findings.

Item Type: Article
Keywords: MRI; autoimmune; hypoadrenocorticism; diabetes insipidus
Schools/Departments: University of Nottingham, UK > Faculty of Medicine and Health Sciences > School of Veterinary Medicine and Science
Identification Number: https://doi.org/10.1111/jvim.14790
Depositing User: Eprints, Support
Date Deposited: 25 May 2017 12:05
Last Modified: 10 Jun 2018 19:56
URI: http://eprints.nottingham.ac.uk/id/eprint/43226

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