Activation induced changes in GABA: functional MRS at 7 T with MEGA-sLASER

Chen, Chen and Sigurdsson, Hilmar P. and Pépés, Sophia E. and Auer, Dorothee P. and Morris, Peter G. and Morgan, Paul S. and Gowland, Penny A. and Jackson, Stephen R. (2017) Activation induced changes in GABA: functional MRS at 7 T with MEGA-sLASER. NeuroImage, 156 . pp. 207-213. ISSN 1095-9572 (In Press)

[img] PDF - Repository staff only until 19 May 2018. - Requires a PDF viewer such as GSview, Xpdf or Adobe Acrobat Reader
Available under Licence Creative Commons Attribution Non-commercial No Derivatives.
Download (531kB)

Abstract

Functional magnetic resonance spectroscopy (fMRS) has been used to assess the dynamic metabolic responses of the brain to a physiological stimulus non-invasively. However, only limited information on the dynamic functional response of γ-aminobutyric acid (GABA), the primary inhibitory neurotransmitter in the brain, is available. We aimed to measure the activation-induced changes in GABA unambiguously using a spectral editing method, instead of the conventional direct detection techniques used in previous fMRS studies. The Mescher-Garwood-semi-localised by adiabatic selective refocusing (MEGA-sLASER) sequence was developed at 7 T to obtain the time course of GABA concentration without macromolecular contamination. A significant decrease (−12±5%) in the GABA to total creatine ratio (GABA/tCr) was observed in the motor cortex during a period of 10 minutes of hand-clenching, compared to an initial baseline level (GABA/tCr = 0.11±0.02) at rest. An increase in the Glx (glutamate and glutamine) to tCr ratio was also found, which is in agreement with previous findings. In contrast, no significant changes in NAA/tCr and tCr were detected. With consistent and highly efficient editing performance for GABA detection and the advantage of visually identifying GABA resonances in the spectra, MEGA-sLASER is demonstrated to be an effective method for studying of dynamic changes in GABA at 7 T.

Item Type: Article
Keywords: GABA; MEGA editing; functional MRS; motor cortex; 7T
Schools/Departments: University of Nottingham, UK > Faculty of Medicine and Health Sciences > School of Medicine
University of Nottingham, UK > Faculty of Science > School of Psychology
Identification Number: 10.1016/j.neuroimage.2017.05.044
Depositing User: Eprints, Support
Date Deposited: 23 May 2017 08:45
Last Modified: 13 Oct 2017 00:20
URI: http://eprints.nottingham.ac.uk/id/eprint/43021

Actions (Archive Staff Only)

Edit View Edit View