Antioxidant properties of novel dimers derived from natural β‑elemene through inhibiting H2O2‑induced apoptosis

Chen, Jichao and Wang, Ruifan and Wang, Tianyu and Ding, Qilong and Khalil, Aliahmad and Xu, Shengtao and Lin, Aijun and Yao, Hequan and Xie, Weijia and Zhu, Zheying and Xu, Jinyi (2017) Antioxidant properties of novel dimers derived from natural β‑elemene through inhibiting H2O2‑induced apoptosis. ACS Medicinal Chemistry Letters, 8 (4). pp. 443-448. ISSN 1948-5875

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Abstract

A series of novel β-elemene dimer derivatives were synthesized and evaluated for their antioxidant activities. The results indicated that most of the target compounds showed more potent cytoprotective effects than positive control vitamin E. In particular, dimer D5 exhibited the strongest antioxidant activity, which was significantly superior to the active compound D1 obtained in our previous study. Besides, D5 did not produce obvious cytotoxicity in normal human umbilical vein endothelial cells (HUVECs) and increased the viability of HUVECs injured by H2O2 in a concentration-dependent manner. Further studies suggested that the cytoprotective action of D5 might be mediated, at least in part, by increasing the intracellular superoxide dismutase activity and nitric oxide secretion as well as decreasing the intracellular malonyldialdehyde content and lactate dehydrogenase release. Furthermore, D5 observably inhibited ROS generation and prevented H2O2-induced apoptosis in HUVECs possibly via inhibiting the activation of the MAPK signaling pathway.

Item Type: Article
Additional Information: This document is the Accepted Manuscript version of a Published Work that appeared in final form in ACS Medicinal Chemistry Letters copyright © 2017 American Chemical Society after peer review and technical editing by the publisher. To access the final edited and published work see http://pubs.acs.org/doi/abs/10.1021/acsmedchemlett.7b00035
Keywords: antioxidant activity; apoptosis; dimer; MAPK pathway; β-Elemene
Schools/Departments: University of Nottingham, UK > Faculty of Science > School of Pharmacy
Identification Number: 10.1021/acsmedchemlett.7b00035
Depositing User: Zhu, Zheying
Date Deposited: 17 May 2017 13:34
Last Modified: 13 Oct 2017 00:29
URI: http://eprints.nottingham.ac.uk/id/eprint/42901

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