Methods for assessing the regenerative responses of neural tissue

Poser, Steven W. and Rueger, Maria Adele and Androutsellis-Theotokis, Andreas (2014) Methods for assessing the regenerative responses of neural tissue. In: Animal models for stem cell therapy. Methods in molecular biology, V (1213). Springer, pp. 293-302. ISBN 9781493914531

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Abstract

In order to establish novel therapeutic paradigms and advance the field of regenerative medicine, methods for their effective implementation as well as rigorous assessment of outcomes are critical. This is especially evident and challenging in the context of treating complex and devastating neurodegenerative disorders, such as Parkinson’s disease, multiple sclerosis, and ischemic stroke. Stem cell-based approaches offer great promise in addressing these conditions. Here, we demonstrate an approach for identifying factors that mobilize endogenous neural stem cells in the repair and recovery of the central nervous system of rodents, involving site-specific administration of growth factors that activate particular signal transduction pathways, and that allows for the assessment of outcome utilizing magnetic resonance imaging and immunohistochemistry.

Item Type: Book Section
Keywords: Stem cells; Regenerative medicine; Neurodegeneration; Magnetic resonance imaging; Immunohistochemistry
Schools/Departments: University of Nottingham, UK > Faculty of Medicine and Health Sciences > School of Medicine > Division of Cancer and Stem Cells
Identification Number: 10.1007/978-1-4939-1453-1_24
Depositing User: Eprints, Support
Date Deposited: 12 May 2017 13:13
Last Modified: 13 May 2017 16:40
URI: http://eprints.nottingham.ac.uk/id/eprint/42829

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