Rational drug repurposing using sscMap analysis in a HOX-TALE model of leukemia

Kettyle, Laura M.J. and Liberante, Fabio G. and Thompson, Alexander (2014) Rational drug repurposing using sscMap analysis in a HOX-TALE model of leukemia. Methods in Molecular Biology, 1196 . pp. 349-370. ISSN 1940-6029

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Abstract

Drug discovery and development are often hampered by lack of target identification and clinical tractability. Repurposing of approved drugs to life-threatening diseases such as leukemia is emerging as a promising alternative approach. Connectivity mapping systems link approved drugs with disease-related gene signatures. Relevant preclinical models provide essential tools for system validation and proof-of-concept studies. Herein we describe procedures aimed at generating disease-based gene signatures and applying them to established cross-referencing databases of potential candidate drugs. As a proof of principle, we present the identification of Entinostat as a candidate drug for the treatment of HOX TALE-related leukemia.

Item Type: Article
Additional Information: The final publication is available at Springer via http://dx.doi.org/10.1007/978-1-4939-1242-1_21
Keywords: HOXA9 Meis1 Data mining Gene expression profiles Connectivity mapping (sscMap) Leukemia Entinostat Preclinical model
Schools/Departments: University of Nottingham, UK > Faculty of Medicine and Health Sciences > School of Medicine > Division of Cancer and Stem Cells
Identification Number: 10.1007/978-1-4939-1242-1_21
Depositing User: Eprints, Support
Date Deposited: 12 May 2017 11:18
Last Modified: 13 Oct 2017 00:37
URI: http://eprints.nottingham.ac.uk/id/eprint/42819

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