STAT3-Ser/Hes3 signaling: a new molecular component of the neuroendocrine system?

Nikolakopoulou, P. and Poser, S.W. and Masjkur, J. and Fernandez Rubin de Celis, M. and Toutouna, L. and Andoniadou, C.L. and McKay, R.D. and Chrousos, G. and Ehrhart-Bornstein, M. and Bornstein, S.R. and Androutsellis-Theotokis, A. (2016) STAT3-Ser/Hes3 signaling: a new molecular component of the neuroendocrine system? Hormone and Metabolic Research, 48 (02). pp. 77-82. ISSN 1439-4286

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Abstract

The endocrine system involves communication among different tissues in distinct organs, including the pancreas and components of the Hypothalamic- Pituitary-Adrenal Axis. The molecular mechanisms underlying these complex interactions are a subject of intense study as they may hold clues for the progression and treatment of a variety of metabolic and degenerative diseases. A plethora of signaling pathways, activated by hormones and other endocrine factors have been implicated in this communication. Recent advances in the stem cell field introduce a new level of complexity: adult progenitor cells appear to utilize distinct signaling pathways than the more mature cells in the tissue they co-reside. It is therefore important to elucidate the signal transduction requirements of adult progenitor cells in addition to those of mature cells. Recent evidence suggests that a common non-canonical signaling pathway regulates adult progenitors in several different tissues, rendering it as a potentially valuable starting point to explore their biology. The STAT3- Ser/Hes3 Signaling Axis was first identified as a major regulator of neural stem cells and, subsequently, cancer stem cells. In the endocrine/neuroendocrine system, this pathway operates on several levels, regulating other types of plastic cells: (a) it regulates pancreatic islet cell function and insulin release; (b) insulin in turn activates the pathway in broadly distributed neural progenitors and possibly also hypothalamic tanycytes, cells with important roles in the control of the adrenal gland; (c) adrenal progenitors themselves operate this pathway. The STAT3-Ser/Hes3 Signaling Axis therefore deserves additional research in the context of endocrinology.

Item Type: Article
Keywords: STAT3, Hes3, stem cells
Schools/Departments: University of Nottingham, UK > Faculty of Medicine and Health Sciences > School of Medicine > Division of Cancer and Stem Cells
Identification Number: 10.1055/s-0041-111699
Depositing User: Eprints, Support
Date Deposited: 10 May 2017 13:00
Last Modified: 16 May 2017 09:50
URI: http://eprints.nottingham.ac.uk/id/eprint/42715

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