Ventral striatum connectivity during reward anticipation in adolescent smokersTools Jollans, Lee, Zhipeng, Cao, Icke, Ilknur, Greene, Ciara, Kelly, Clare, Banaschewski, Tobias, Bokde, Arun L. W., Bromberg, Uli, Büchel, Christian, Cattrell, Anna, Conrod, Patricia J., Desrivières, Sylvane, Flor, Herta, Frouin, Vincent, Gallinat, Jürgen, Garavan, Hugh, Gowland, Penny, Heinz, Andreas, Ittermann, Bernd, Martinot, Jean-Luc, Artiges, Eric, Nees, Frauke, Papadopoulos Orfanos, Dimitri, Paus, Tomáš, Smolka, Michael N., Walter, Henrik, Schumann, Gunter and Whelan, Robert (2016) Ventral striatum connectivity during reward anticipation in adolescent smokers. Developmental Neuropsychology, 41 (1-2). pp. 6-21. ISSN 1532-6942 Full text not available from this repository.AbstractSubstance misusers, including adolescent smokers, often have reduced reward system activity during processing of non-drug rewards. Using a psychophysiological interaction approach, we examined functional connectivity with the ventral striatum during reward anticipation in a large (N = 206) sample of adolescent smokers. Increased smoking frequency was associated with (1) increased connectivity with regions involved in saliency and valuation, including the orbitofrontal cortex and (2) reduced connectivity between the ventral striatum and regions associated with inhibition and risk aversion, including the right inferior frontal gyrus. These results demonstrate that functional connectivity during reward processing is relevant to adolescent addiction.
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