Neural basis of reward anticipation and its genetic determinants

Jia, Tianye and Macare, Christine and Desrivières, Sylvane and Gonzalez, Dante A. and Tao, Chenyang and Ji, Xiaoxi and Ruggeri, Barbara and Nees, Frauke and Banaschewski, Tobias and Barker, Gareth J. and Bokde, Arun L. W. and Bromberg, Uli and Büchel, Christian and Conrod, Patricia J. and Dove, Rachel and Frouin, Vincent and Gallinat, Jürgen and Garavan, Hugh and Gowland, Penny A. and Heinz, Andreas and Ittermann, Bernd and Lathrop, Mark and Lemaitre, Hervé and Martinot, Jean-Luc and Paus, Tomáš and Pausova, Zdenka and Poline, Jean-Baptiste and Rietschel, Marcella and Robbins, Trevor and Smolka, Michael N. and Müller, Christian P. and Feng, Jianfeng and Rothenfluh, Adrian and Flor, Herta and Schumann, Gunter (2016) Neural basis of reward anticipation and its genetic determinants. Proceedings of the National Academy of Sciences, 113 (14). pp. 3879-3884. ISSN 1091-6490

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Abstract

Dysfunctional reward processing is implicated in various mental disorders, including attention deficit hyperactivity disorder (ADHD) and addictions. Such impairments might involve different components of the reward process, including brain activity during reward anticipation. We examined brain nodes engaged by reward anticipation in 1,544 adolescents and identified a network containing a core striatal node and cortical nodes facilitating outcome prediction and response preparation. Distinct nodes and functional connections were preferentially associated with either adolescent hyperactivity or alcohol consumption, thus conveying specificity of reward processing to clinically relevant behavior. We observed associations between the striatal node, hyperactivity, and the vacuolar protein sorting-associated protein 4A (VPS4A) gene in humans, and the causal role of Vps4 for hyperactivity was validated in Drosophila. Our data provide a neurobehavioral model explaining the heterogeneity of reward-related behaviors and generate a hypothesis accounting for their enduring nature.

Item Type: Article
Schools/Departments: University of Nottingham, UK > Faculty of Science > School of Physics and Astronomy
Identification Number: 10.1073/pnas.1503252113
Depositing User: Eprints, Support
Date Deposited: 09 May 2017 08:49
Last Modified: 14 May 2017 08:09
URI: http://eprints.nottingham.ac.uk/id/eprint/42632

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