Adrenal cortical and chromaffin stem cells: Is there a common progeny related to stress adaptation?

Steenblock, Charlotte and de Celis, Maria F. Rubin and Androutsellis-Theotokis, Andreas and Sue, Mariko and Delgadillo Silva, Luis F. and Eisenhofer, Graeme and Andoniadou, Cynthia L. and Bornstein, Stefan R. (2017) Adrenal cortical and chromaffin stem cells: Is there a common progeny related to stress adaptation? Molecular and Cellular Endocrinology, 441 . pp. 156-163. ISSN 1872-8057

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Abstract

The adrenal gland is a highly plastic organ with the capacity to adapt the body homeostasis to different physiological needs. The existence of stem-like cells in the adrenal cortex has been revealed in many studies. Recently, we identified and characterized in mice a pool of glia-like multipotent Nestin-expressing progenitor cells, which contributes to the plasticity of the adrenal medulla. In addition, we found that these Nestin progenitors are actively involved in the stress response by giving rise to chromaffin cells. Interestingly, we also observed a Nestin-GFP-positive cell population located under the adrenal capsule and scattered through the cortex. In this article, we discuss the possibility of a common progenitor giving rise to subpopulations of cells both in the adrenal cortex and medulla, the isolation and characterization of this progenitor as well as its clinical potential in transplantation therapies and in pathophysiology.

Item Type: Article
Keywords: adrenal medulla, adrenal cortex, stem cells, progenitors, stress, nestin
Schools/Departments: University of Nottingham, UK > Faculty of Medicine and Health Sciences > School of Medicine > Division of Cancer and Stem Cells
Identification Number: 10.1016/j.mce.2016.09.011
Depositing User: Eprints, Support
Date Deposited: 09 May 2017 08:18
Last Modified: 12 May 2017 12:53
URI: http://eprints.nottingham.ac.uk/id/eprint/42618

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