Three-dimensional ex vivo co-culture models of the leukaemic bone marrow niche for functional drug testing

Dhami, Sukhraj Pal S. and Kappala, Shanthi S. and Thompson, Alexander and Szegezdi, Eva (2016) Three-dimensional ex vivo co-culture models of the leukaemic bone marrow niche for functional drug testing. Drug Discovery Today, 21 (9). pp. 1464-1471. ISSN 1878-5832

[img] PDF - Repository staff only - Requires a PDF viewer such as GSview, Xpdf or Adobe Acrobat Reader
Download (1MB)

Abstract

Acute myeloid leukaemia (AML) is a hierarchically structured malignancy in which aberrant leukemic stem cells drive the production of leukaemic blast cell clones. AML cells strictly depend on the bone marrow microenvironment (BMM) in which they reside. Classical AML cell cultures fail to mimic the BMM and, therefore, drug discovery studies are dominated by in vivo models. However, animal models are time consuming, labour intensive, provide limited mechanistic insight, and are unsuited for high throughput studies, necessitating the development of novel AML models. The evolving ex vivo BMM mimicking culture systems aim to fill this gap, with increasing success. Here, we discuss how AML microenvironment co-culture models advance our understanding of this disease, and highlight their future potential for translational AML research.

Item Type: Article
Schools/Departments: University of Nottingham, UK > Faculty of Medicine and Health Sciences > School of Medicine
Identification Number: 10.1016/j.drudis.2016.04.019
Depositing User: Eprints, Support
Date Deposited: 09 May 2017 07:51
Last Modified: 11 May 2017 14:41
URI: http://eprints.nottingham.ac.uk/id/eprint/42608

Actions (Archive Staff Only)

Edit View Edit View