A methodology for elucidating regulatory mechanisms leading to changes in lipid profiles

Casbas-Pinto, Ferran and Ravipati, Srinivarao and Barrett, David A. and Hodgman, Charlie (2017) A methodology for elucidating regulatory mechanisms leading to changes in lipid profiles. Metabolomics, 13 . 81/1-81/4. ISSN 1573-3890

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Abstract

Introduction

It is difficult to elucidate the metabolic and regulatory factors causing lipidome perturbations.

Objectives

This work simplifies this process.

Methods

A method has been developed to query an online holistic lipid metabolic network (of 7923 metabolites) to extract the pathways that connect the input list of lipids.

Results

The output enables pathway visualisation and the querying of other databases to identify potential regulators. When used to a study a plasma lipidome dataset of polycystic ovary syndrome, 14 enzymes were identified, of which 3 are linked to ELAVL1—an mRNA stabiliser.

Conclusion

This method provides a simplified approach to identifying potential regulators causing lipid-profile perturbations.

Item Type: Article
Schools/Departments: University of Nottingham, UK > Faculty of Science > School of Biosciences > Division of Agricultural and Environmental Sciences
University of Nottingham, UK > Faculty of Science > School of Pharmacy
Identification Number: 10.1007/s11306-017-1214-y
Depositing User: Jacob, Mr Tim
Date Deposited: 05 Jan 2018 12:38
Last Modified: 05 Jan 2018 12:45
URI: http://eprints.nottingham.ac.uk/id/eprint/42506

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