Mortality in systemic lupus erythematosus in the United Kingdom 1999-2012

Rees, Frances and Doherty, Michael and Grainge, Matthew J. and Lanyon, Peter and Davenport, Graham and Zhang, Weiya (2016) Mortality in systemic lupus erythematosus in the United Kingdom 1999-2012. Rheumatology, 55 (5). pp. 854-860. ISSN 1462-0332

[img] PDF - Repository staff only - Requires a PDF viewer such as GSview, Xpdf or Adobe Acrobat Reader
Download (206kB)

Abstract

OBJECTIVES: To estimate the mortality associated with SLE during the period 1999-2012 by age, gender and region; and to ascertain the cause of death for people with SLE.

METHODS: A retrospective cohort study using the UK Clinical Practice Research Datalink. Incident SLE cases diagnosed between 1999 and 2012 were matched by age, sex and practice to four controls. Age-, gender- and region-specific mortality rates were calculated per 1000 person-years and compared with control mortality rates using mortality rate ratios (MRRs). For individuals with linked Office of National Statistics data, cause of death was summarized by International Classification of Disease-10 chapter heading.

RESULTS: Of 2740 incident cases, 227 died, giving a mortality rate of 15.84/1000 person-years (95% CI 13.91, 18.04). This was 67% higher than in controls (MRR 1.67, 95% CI 1.43, 1.94, P < 0.001). Men with SLE had higher rates of mortality than females with SLE. Compared with controls, the mortality rate for males with SLE was 1.80 times that of male controls (95% CI 1.32, 2.45, P < 0.001); for females the mortality rate was 1.64 times higher (95% CI 1.37, 1.96, P < 0.001). The age-specific mortality rates increased significantly with age; however, the MRR diminished from 3.81 (95% CI 1.43, 10.14) in those aged <40 years to 0.82 (95% CI 0.36, 1.83) in those 90 years. There was no significant difference in mortality between regions. Circulatory system disease and malignancy were the most frequent causes of death in both cases and controls.

CONCLUSION: There remains an increased mortality for people with SLE compared with matched controls, particularly at younger ages.

Item Type: Article
Additional Information: This is a pre-copyedited, author-produced version of an article accepted for publication in Rheumatology following peer review. The version of record Frances Rees, Michael Doherty, Matthew J. Grainge, Peter Lanyon, Graham Davenport, Weiya Zhang; Mortality in systemic lupus erythematosus in the United Kingdom 1999–2012. Rheumatology (Oxford) 2016; 55 (5): 854-860. doi: 10.1093/rheumatology/kev424 is available online at: https://academic.oup.com/rheumatology/article-lookup/doi/10.1093/rheumatology/kev424
Keywords: Adult, Age Distribution, Aged 80 and over, Cause of Death, Databases, Factual, Systemic Lupus Erythematosus, Clinical Practice Research Datalink, Mortality, Epidemiology Female Humans Lupus Erythematosus, Systemic/*mortality Male Middle Aged Retrospective Studies Sex Characteristics Sex Distribution Time Factors United Kingdom/epidemiology clinical practice research datalink epidemiology mortality systemic lupus erythematosus
Schools/Departments: University of Nottingham, UK > Faculty of Medicine and Health Sciences > School of Medicine > Division of Epidemiology and Public Health
University of Nottingham, UK > Faculty of Medicine and Health Sciences > School of Medicine > Division of Rheumatology, Orthopaedics and Dermatology
Identification Number: 10.1093/rheumatology/kev424
Depositing User: Claringburn, Tara
Date Deposited: 27 Apr 2017 08:22
Last Modified: 13 Oct 2017 00:58
URI: http://eprints.nottingham.ac.uk/id/eprint/42278

Actions (Archive Staff Only)

Edit View Edit View