Kuo, Chang-Fu, Grainge, Matthew J., Mallen, Christian, Zhang, Weiya and Doherty, Michael
(2016)
Comorbidities in patients with gout prior to and following diagnosis: case-control study.
Annals of the Rheumatic Diseases, 75
(1).
pp. 210-217.
ISSN 1468-2060
Full text not available from this repository.
Abstract
OBJECTIVES: To determine the burden of comorbidities in patients with gout at diagnosis and the risk of developing new comorbidities post diagnosis.
METHODS: There were 39 111 patients with incident gout and 39 111 matched controls identified from the UK Clinical Practice Research Data-link. The risk of comorbidity before (ORs) and after the diagnosis of gout (HRs) were estimated, adjusted for age, sex, diagnosis year, body mass index, smoking and alcohol consumption.
RESULTS: Gout was associated with adjusted ORs (95% CIs) of 1.39 (1.34 to 1.45), 1.89 (1.76 to 2.03) and 2.51 (2.19 to 2.86) for the Charlson index of 1-2, 3-4 and >/=5, respectively. Cardiovascular and genitourinary diseases, in addition to hyperlipidaemia, hypothyroidism, anaemia, psoriasis, chronic pulmonary diseases, osteoarthritis and depression, were associated with a higher risk for gout. Gout was also associated with an adjusted HR (95% CI) of 1.41 (1.34 to 1.48) for having a Charlson index >/=1. Median time to first comorbidity was 43 months in cases and 111 months in controls. Risks for incident comorbidity were higher in cardiovascular, genitourinary, metabolic/endocrine and musculoskeletal diseases, in addition to liver diseases, hemiplegia, depression, anaemia and psoriasis in patients with gout. After additionally adjusting for all comorbidities at diagnosis, gout was associated with a HR (95% CI) for all-cause mortality of 1.13 (1.08 to 1.18; p<0.001).
CONCLUSIONS: The majority of patients with gout have worse pre-existing health status at diagnosis and the risk of incident comorbidity continues to rise following diagnosis. The range of associated comorbidities is broader than previously recognised and merits further evaluation.
| Item Type: |
Article
|
| RIS ID: |
https://nottingham-repository.worktribe.com/output/767943 |
| Keywords: |
Aged, Case-control studies, Comorbidity, Databases, Factual, Female, Follow-up studies, Gout/epidemiology, Humans, Male, Middle aged, Retrospective studies, United Kingdom/epidemiology, Cardiovascular disease, Epidemiology, Gout |
| Schools/Departments: |
University of Nottingham, UK > Faculty of Medicine and Health Sciences > School of Medicine > Division of Epidemiology and Public Health
University of Nottingham, UK > Faculty of Medicine and Health Sciences > School of Medicine > Division of Rheumatology, Orthopaedics and Dermatology |
| Identification Number: |
10.1136/annrheumdis-2014-206410 |
| Depositing User: |
Claringburn, Tara
|
| Date Deposited: |
19 Apr 2017 07:42 |
| Last Modified: |
15 Aug 2024 15:17 |
| URI: |
https://eprints.nottingham.ac.uk/id/eprint/41930 |
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