Campylobacter jejuni gene cj0511 encodes a serine peptidase essential for colonisation

Karlyshev, A.V. and Thacker, G. and Jones, M.A. and Clements, M.O. and Wren, Brendan W. (2014) Campylobacter jejuni gene cj0511 encodes a serine peptidase essential for colonisation. FEBS Open Bio, 4 (1). pp. 468-472. ISSN 2211-5463

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Abstract

According to MEROPS peptidase database, Campylobacter species encode 64 predicted peptidases. However, proteolytic properties of only a few of these proteins have been confirmed experimentally. In this study we identified and characterised a Campylobacter jejuni gene cj0511 encoding a novel peptidase. The proteolytic activity associated with this enzyme was demonstrated in cell lysates. Moreover, enzymatic studies conducted with a purified protein confirmed a prediction of it being a serine peptidase. Furthermore, cj0511 mutant was found to be severely attenuated in chicken colonisation model, suggesting a role of the Cj0511 protein in infection.

Item Type: Article
RIS ID: https://nottingham-repository.worktribe.com/output/728878
Keywords: Campylobacter, Protease, Colonisation, Chicken
Schools/Departments: University of Nottingham, UK > Faculty of Medicine and Health Sciences > School of Veterinary Medicine and Science
Identification Number: https://doi.org/10.1016/j.fob.2014.04.012
Depositing User: Jones, Michael
Date Deposited: 06 Apr 2017 07:37
Last Modified: 04 May 2020 16:48
URI: http://eprints.nottingham.ac.uk/id/eprint/41765

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