The genomic architecture of resistance to Campylobacter jejuni intestinal colonisation in chickens

Psifidi, A. and Fife, M. and Howell, J. and Matika, O. and van Diemen, P.M. and Kuo, Richard and Smith, J. and Hockling, P.M. and Salmon, N. and Jones, M.A. and Hume, D.A. and Banos, G. and Stevens, M.P. and Kaiser, P. (2016) The genomic architecture of resistance to Campylobacter jejuni intestinal colonisation in chickens. BMC Genomics, 17 . 293/1-293/18. ISSN 1471-2164

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Abstract

Campylobacter is the leading cause of foodborne diarrhoeal illness in humans and is mostly acquired from consumption or handling of contaminated poultry meat. In the absence of effective licensed vaccines and inhibitors, selection for chickens with increased resistance to Campylobacter could potentially reduce its subsequent entry into the food chain. Campylobacter intestinal colonisation levels are influenced by the host genetics of the chicken. In the present study, two chicken populations were used to investigate the genetic architecture of avian resistance to colonisation: (i) a back-cross of two White Leghorn derived inbred lines [(61 x N) x N] known to differ in resistance to Campylobacter colonisation and (ii) a 9th generation advanced intercross (61 x N) line.

Item Type: Article
Keywords: Campylobacter, Chicken, Colonisation, Genetics, Resistance
Schools/Departments: University of Nottingham, UK > Faculty of Medicine and Health Sciences > School of Veterinary Medicine and Science
Identification Number: 10.1186/s12864-016-2612-7
Depositing User: Jones, Michael
Date Deposited: 06 Apr 2017 07:15
Last Modified: 13 Oct 2017 01:13
URI: http://eprints.nottingham.ac.uk/id/eprint/41760

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