Iron(II) catalyzed hydrophosphination of isocyanates

Sharpe, Helen R. and Geer, Ana M. and Lewis, William and Blake, Alexander J. and Kays, Deborah L. (2017) Iron(II) catalyzed hydrophosphination of isocyanates. Angewandte Chemie International Edition, 56 (17). pp. 4845-4848. ISSN 1521-3773

[img] PDF - Repository staff only until 24 March 2018. - Requires a PDF viewer such as GSview, Xpdf or Adobe Acrobat Reader
Download (1MB)

Abstract

The first transition metal catalyzed hydrophosphination of isocyanates is presented. The use of low-coordinate iron(II) precatalysts leads to an unprecedented catalytic double insertion of isocyanates into the P-H bond of diphenylphosphine to yield phosphinodicarboxamides [Ph2PC(=O)N(R)C(=O)N(H)R], a new family of derivatized organophosphorus compounds. This remarkable result can be attributed to the low-coordinate nature of the iron(II) centres whose inherent electron deficiency enables a Lewis-acid mechanism in which a combination of the steric pocket of the metal centre and substrate size determines the reaction products and regioselectivity.

Item Type: Article
Additional Information: This is the peer reviewed version of the following article: H. R. Sharpe, A. M. Geer, W. Lewis, A. J. Blake, D. L. Kays, Angew. Chem. Int. Ed. 2017, 56, 4845. doi:10.1002/anie.201701051, which has been published in final form at http://onlinelibrary.wiley.com/doi/10.1002/anie.201701051/abstract. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving.
Keywords: Hydrophosphination, Iron, Isocyanates, m-terphenyl ligands, Homogeneous catalysis
Schools/Departments: University of Nottingham, UK > Faculty of Science > School of Chemistry
Identification Number: 10.1002/anie.201701051
Depositing User: Smith, Ruth
Date Deposited: 04 Apr 2017 14:11
Last Modified: 08 May 2017 18:14
URI: http://eprints.nottingham.ac.uk/id/eprint/41735

Actions (Archive Staff Only)

Edit View Edit View