Genome-wide association studies in asthma

Portelli, Michael A. and Sayers, Ian (2016) Genome-wide association studies in asthma. eLS . pp. 1-10.

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Abstract

Asthma is a complex respiratory disease, with both genetic and environmental factors contributing to disease susceptibility. Genome-wide association studies (GWAS) have now identified novel risk alleles and loci associated with asthma diagnosis and more recently with clinical subgroups of disease. However, while providing insight into potential disease mechanisms these risk alleles have modest effect sizes and account for a small proportion of the anticipated heritability of asthma. In this article we provide an overview of GWAS in asthma to date including reproducible associations and advances in our understanding of the biology of asthma. In addition we discuss ancestry-specific findings and how genetics may contribute to the development of multiple allergic conditions known as the ‘atopic march’. Finally, we outline the strengths and weaknesses of GWAS and look to future approaches including a greater focus to functional variation and assessment of gene–gene and gene–environment interactions.

Item Type: Article
Additional Information: This is the peer reviewed version of the following article: Portelli, M. and Sayers, I. 2016. Genome-Wide Association Studies in Asthma. eLS. 1–10. which has been published in final form at http://onlinelibrary.wiley.com/doi/10.1002/9780470015902.a0024639/full This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving.
Keywords: Asthma; Genome-wide association study; Single nucleotide polymorphism; Heritability; Atopic march
Schools/Departments: University of Nottingham, UK > Faculty of Medicine and Health Sciences > School of Medicine > Division of Respiratory Medicine
Identification Number: 10.1002/9780470015902.a0024639
Depositing User: Eprints, Support
Date Deposited: 29 Mar 2017 09:55
Last Modified: 29 Mar 2017 09:59
URI: http://eprints.nottingham.ac.uk/id/eprint/41624

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