Exercise metabolism in non-obese patients with type 2 diabetes following the acute restoration of normoglycaemia

Gaffney, Christopher J. and Mansell, Peter and Stephens, Francis B. and MacDonald, Ian A. and Tsintzas, Kostas (2017) Exercise metabolism in non-obese patients with type 2 diabetes following the acute restoration of normoglycaemia. Journal of Diabetes Research, 2017 . 8248725/1-8248725/8. ISSN 2314-6753

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Abstract

This study investigated how acute restoration of normoglycaemia affected energy metabolism during exercise in nonobese patients with type 2 diabetes. Six subjects (mean ± SEM) aged 56.2 ± 2.7 years, with a BMI of 24.5 ± 1.5 kg/m2 and a VO2 peak of 28.7 ml/kg/min, attended the lab on two randomised occasions for a four-hour resting infusion of insulin or saline, followed by 30 minutes cycling at 50% VO2 peak. During the 4 h resting infusion, there was a greater (P < 0 0001) reduction in blood glucose in insulin treatment (INS) (from 11.2 ± 0.6 to 5.6 ± 0.1 mmol/l) than in saline treatment/control (CON) (from 11.5 ± 0.7 to 8.5 ± 0.6 mmol/l). This was associated with a lower (P < 0 05) resting metabolic rate in INS (3.87 ± 0.17) than in CON (4.39 ± 0.30 kJ/min). During subsequent exercise, blood glucose increased significantly in INS from 5.6 ± 0.1 at 0 min to 6.3 ± 0.3 mmol/l at 30 min (P < 0 01), which was accompanied by a lower blood lactate response (P < 0 05). Oxygen uptake, rates of substrate utilization, heart rate, and ratings of perceived exertion were not different between trials. Insulin-induced normoglycaemia increased blood glucose during subsequent exercise without altering overall substrate utilization.

Item Type: Article
Keywords: Non-obese, Type 2 diabetes, Exercise, Cycling
Schools/Departments: University of Nottingham, UK > Faculty of Medicine and Health Sciences > School of Life Sciences
Identification Number: 10.1155/2017/8248725
Depositing User: Eprints, Support
Date Deposited: 27 Mar 2017 13:15
Last Modified: 03 Nov 2017 04:06
URI: http://eprints.nottingham.ac.uk/id/eprint/41589

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