Microscale coiling in bis-imidazolium supramolecular hydrogel fibres induced by release of a cationic serine protease inhibitor

Limón, David and Jiménez-Newman, Claire and Calpena, Ana C. and Gonzalez-Campo, Arántzazu and Amabilino, David A. and Pérez-García, Lluïsa (2017) Microscale coiling in bis-imidazolium supramolecular hydrogel fibres induced by release of a cationic serine protease inhibitor. Chemical Communications, 53 . pp. 1433-1434. ISSN 1364-548X

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Abstract

Gels formed by a gemini dicationic amphiphile incorporate a serine protease inhibitor, which could be used in a new approach to the treatment of Rosacea, within the fibres as well as in the space between them, affecting a number of gel properties but most importantly inducing remarkable fibre coiling at the microscopic level as a result of drug release from the gel. Drug release and skin permeation experiments show its potential for topical administration.

Item Type: Article
Schools/Departments: University of Nottingham, UK > Faculty of Science > School of Chemistry
Identification Number: 10.1039/C6CC09392B
Depositing User: Bramwell, Roseanna
Date Deposited: 24 Mar 2017 15:54
Last Modified: 13 Oct 2017 01:17
URI: http://eprints.nottingham.ac.uk/id/eprint/41547

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